High Shear Granulation

This is the most common configuration used at an industrial scale for the production of pharmaceutical granules (Figure 3). Again, this system allows full integration with upstream and downstream equipment, and even includes a wet mill between the granulator and dryer. With modern control systems it is easy to load, mix and granulate a second batch in the high shear granulator whilst drying the previous batch in the fluid bed prior to discharge. All equipment can be CIP in a single automatic process.Whereas a single shaker might be acceptable for drying applications, a twin shaker or blowback filter design should be used for granulation processes.

Figure 3 A typical set-up installation at an industrial scale for the production of pharmaceutical granules