The manufacture of pharmaceutical products from blood plasma by plasma fractionation requires process conditions that are particularly kind to the product. It is done to the greatest possible extent under sterile conditions, and requires materials and processing of the highest quality. In addition, a large number of national and international standards and statutory provisions have to be complied with. Manufacturers therefore expect great precision in the manufacture and assembly of their process plant. Every detail of the design must comply with high-quality standards, in order to avoid production errors. If these conditions are fulfilled by high-performance processing equipment, reliable production is guaranteed.

Whatever it is you need your process plant for - the fractionation and manufacture of products from immunoglobulins, human albumins, Factor VIII, Factor IX or whatever - our great diversity of plant concepts will provide for any task to be performed and take account of any requirements or conditions. By using the latest components and valve technology and the latest, state-of-the-art manufacturing concepts for containers and skids, we ensure that you will be able to use your plant to manufacture your products in a manner that is both economic and kind to the source materials.

Technologies used:

  • centrifugation and filtration for solid/liquid separation
  • thermal and chemical inactivation procedure
  • ultrafiltration/diafiltration
  • nanofiltration
  • chromatography

Essential process requirements:

  • gentle thawing of the plasma through precise temperature control and regulated stirring
  • appropriate conditions for solid/liquid separation by centrifugation or filtration to separate the plasma fractions
  • special filtration techniques to gain eluate for the manufacture of Factor IX
  • exact temperature control for the precipitation of all fractions
  • design free of dead-leg areas
  • compliance with emission regulations when dosing the precipitation medium

GEA Liquid Processing (GEA Diessel) supplies plant and components for:

  • fractionation
  • concentration
  • pre- and post-virus inactivation
  • purification
  • buffer production, storage and distribution

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