For cell rupture and particle size reduction

The GEA Liquid Processing portfolio of technologies includes the Niro Soavi VHP Homogenizer Systems which have become the industry standard for particle size reduction and cell rupture in pharmaceutical and biotech manufacturing. At the core of the Niro Soavi VHP System is the Niro Soavi homogenizer, renowned for its robust design, clean-ability, and ease of maintenance.

For biologic cell lysing, the Niro Soavi VHP Homogenizer System offers distinct advantages over chemical lysing and impinging flow type technologies. Whereas chemical lysing require additional costly purification and recovery process steps to yield the desired product, the Niro Soavi VHP system require no additional processing steps, achieving yields of better than 90% on a single pass. Unlike cell lysing with impinging flow type equipment, the Niro Soavi VHP Systems can be easily scaled from the lab and pilot systems through to the commercial size systems.

Particle size applications for the pharmaceutical industry can be accomplished at lower pressures than competing technologies because of the high efficiency sharp profile rupture valve. Components in the VHP system are constructed of high strength, non-shedding materials so that no unwanted matter contaminates the product.

GEA Niro Soavi Test Center
GEA Niro Soavi Test Center
GEA Niro Soavi NS1001L laboratory table top homogenizer

With thousands of units installed in production facilities operating at continuous duties up to 5,000 LPH and 21,750 PSI pressure, the Niro Soavi VHP Homogenizers and Systems are well proven technology.

GEA Niro Soavi VHP Homogenizer System Models
 
NH 2006-1
NH 3006-1
NH 3006-15
NH 3024-1
NH 3024-15
NH 3037-1
NH 3037-15
Max Pressure (Bar)
1000
1000
1500
1000
1500
1000
1500
Capacity (L/Hr)
80
120
50
500
300
1200
750
Variable Capacity
Optional
Optional
Optional
Yes
Yes
Yes
Yes
Plunger Number
2
3
3
3
3
3
3
Plunger Diameter (mm)
12.7
12.7
10
20
16
30
25
Plunger Stroke (mm)
40
40
40
70
70
70
70
CIP-able
Yes
Yes
Yes
Yes
Yes
Yes
Yes
SIP-able
Optional
Optional
Optional
Optional
Optional
Optional
Optional
System Dimensions Width x Length x Height (mm)
1100 W x 1550 L x 1800 H
1200 W x 1650 L x 1850 H
1200 W x 1650 L x 1850 H
1600 W x 2500 L x 2000 H
1600 W x 2500 L x 2000 H
2000 W x 3000 L x 2000 H
2000 W x 3000 L x 2000 H
System Weight approx (Kg)
1350
1500
1500
2000
2000
3000
3000

 

Utility Requirements
 
NH 2006-1
NH 3006-1
NH 3006-15
NH 3024-1
NH 3024-15
NH 3037-1
NH 3037-15
Max Pressure (Bar)
1000
1000
1500
1000
1500
1000
1500
Capacity (L/Hr)
80
120
50
500
300
1200
750
WFI Plunger Flush (L/Hr) < 60 Deg C
60
60
60
90
90
90
90
Cooling Water Homogenizer Transmission (L/Hr)
N/A
300
N/A
300
300
300
300
MCC Fused Disconnect Size (Amps)
30
30
30
60
60
200
200
3 Phase Power
460
460
460
460
460
460
460
Product Cooler Heat Exchanged (Watts)
2,800
4,200
2,700
17,000
15,500
42,000
40,000
Pneumatic Air Supply (Bar)
6
6
6
6
6
6
6
Required CIP Flow Rate (L/min)
18
18
18
35
35
35
35

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