Pellets via Layering & Pelletizing

Layering from Liquids

A solution or suspension of the active component is sprayed onto inert cores consisting of crystals or non-pareil seeds. This is essentially a multi-layer spray coating process which can be performed in fluid beds, the Precision Coater™ or the Roto-Processor™.

Layering from Powders

The active substance is layered as a powder onto inert cores by simultaneous spraying of a binder liquid. This process is carried out in the Roto-Processor™.

Wet Granulation Pelletizing

A powder mixture of the active component and the excipients is granulated by addition of a binder liquid. The moist granules are then formed into pellets by the mechanical action of an impeller or a rotating disc. Both the high shear Pellet Processor™ and the Roto-Processor™ can be used for this process.

Roto-Processor™

Pellet Processor™

Melt Granulation Pelletizing

A melt binder in powder form is mixed with the active powder in a high shear processor. Through a high mechanical energy input from an impeller the mixture is heated to above the melting point of the binder. This leads to granulation and subsequent forming of pellets without the use of solvents. Only the Pellet Processor™ is suitable for this process.

Extrusion and Spheronizing

Moist granulate is pressed through a screen in a low shear radial extruder and then formed into pellets on a spheronizer.

Blue Pellets

Pink Pellets

Yellow Pellets

The Nica™ System is available as individual granulators, extruders, and spheronizers or as integrated palletizing lines including batch or continuous fluid bed dryers.

Nica™ Extruder / Spheronizer